Fmoc-8-amino-3,6-dioxaoctanoic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fmoc-8-氨基-3,6-二氧辛酸是一种可裂解的 ADC 连接体，用于合成抗体药物偶联物 (ADC)。

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Fmoc-NH-PEG2-CH2COOH

Antibody Drug Conjugates (ADC)

ADCs Linker/Click Chemistry

ADC Linker|PROTAC Linker

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166108-71-0

385.41

C21H23NO6

>98% (HPLC)

DMSO:10 mM

O=C(O)COCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

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(-20℃)

With Ice Pack

≥ 2 years